The reference site for Ranitidine

Ranitidine, sold under the trade name Zantac among others, is a medication that decreases stomach acid production. It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.

WHAT IS RANITIDINE?

Ranitidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Ranitidine also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Ranitidine is in a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces.

Ranitidine is currently marketed by GlaxoSmithKline under the trade name Zantac®.

 

Brand Name(s): Zantac Oral; Zantac AR; Tritec
CAS nº: 66357-35-5
(ra nye’ te deen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to ranitidine and its correct use. Please read them carefully.

FDA Information

Ranitidine has been approved by the Food and Drug Administration.

Ranitidine was first developed by Glaxo (now GlaxoSmithKline) in an effort to match the success of Smith, Kline & French (also now GlaxoSmithKline) with the first histamine H2-receptor antagonist cimetidine. Ranitidine was the result of a rational drug-design process utilising the, by then, fairly refined model of the histamine H2-receptor and quantitative structure-activity relationships.

Glaxo refined the model further by replacing the imidazole-ring of cimetidine with a furan-ring with a nitrogen-containing substituent, and in doing so developed ranitidine. Ranitidine was found to have a far-improved tolerability profile (i.e. fewer adverse drug reactions), longer-lasting action, and ten times the activity of cimetidine.

Ranitidine was introduced in 1981 and was the world’s biggest-selling prescription drug by 1988. It has since largely been superseded by the even more effective proton pump inhibitors, with omeprazole becoming the biggest-selling drug for many years.

In US, GlaxoSmithKline received US FDA approval for Ranitidine 75 mg, the OTC version of the anti-ulcer drug.

Why is this medication prescribed?

Ranitidine is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Ranitidine also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Ranitidine is in a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces.

Ranitidine is currently marketed by GlaxoSmithKline under the trade name Zantac®.

Other uses for this medicine

Ranitidine is also used sometimes to treat upper gastrointestinal bleeding and to prevent stress ulcers, stomach damage from use of nonsteroidal anti-inflammatory medications (NSAIDs), and aspiration of stomach acid during anesthesia.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Ranitidine comes as a tablet, an effervescent tablet, effervescent granules, and a syrup to be taken by mouth.

Take ranitidine exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended nor longer than prescribed.

Take each ranitidine tablet with a full glass of water.

The ranitidine effervescent tablet or granules must be dissolved in water before taking each dose. Tablets or granules should not be chewed, swallowed whole, or dissolved on the tongue.

Place the Zantac 150 mg Efferdose tablet in a full glass (6 to 8 ounces) of water. Allow the tablet to completely dissolve, then drink the entire mixture.

Place the Zantac 25 mg Efferdose tablet in at least 1 teaspoon of water. Allow the tablet to completely dissolve, then drink the entire mixture. If you are giving this medicine to a child, you can place this mixture in a medicine dropper or syringe before giving it to the child.

Ranitidine granules should be mixed with 6 to 8 ounces of water before drinking.

To be sure you get the correct dose, measure the liquid form of ranitidine with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Ranitidine syrup may be given to an infant or child by medicine dropper or oral syringe.

Do not stop taking ranitidine without asking your doctor. It may take up to 8 weeks for an ulcer to heal.

What special precautions should I follow?

BEFORE TAKING RANITIDINE:

Tell your doctor and pharmacist if you are allergic to ranitidine or any other medications.

Inform your doctor and pharmacist what prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention either of the following: anticoagulants (‘blood thinners’) such as warfarin (Coumadin); and triazolam (Halcion). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor if you have or have ever had porphyria, phenylketonuria, or kidney or liver disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.

What side effects can this medication cause?

Common side effects from ranitidine:

headache (may be severe)
decreased sex drive, impotence
swollen or tender breasts (in men)
nausea, vomiting, stomach pain
diarrhea or constipation

Tell your doctor if any of these symptoms are severe or do not go away:

headache
constipation
diarrhea
upset stomach
vomiting
stomach pain

If you experience any of the following symptoms, call your doctor immediately:

allergic reaction (hives, difficulty breathing, swelling of your face, lips, tongue or throat)

Ranitidine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

weakness
lack of coordination
severe nausea or vomiting
fast heartbeat

Product Images

PICTURES OF RANITIDINE PILLS

Below you will find images and specific information on the principal types of ranitidine that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: ZANTAC
Strength(s): 150 MG
Imprint: ZANTAC 150 GLAXO
Manufacturer: GLAXOSMITHKLINE

Name: ZANTAC
Strength(s): 300 MG
Imprint: ZANTAC 300 GLAXO
Manufacturer: GLAXOSMITHKLINE

Name: RANITIDINE
Strength(s): 150 MG
Imprint: GG 614
Manufacturer: SANDOZ

Name: RANITIDINE
Strength(s): 150 MG
Imprint: GG 705
Manufacturer: GENEVA PHARM.

Name: RANITIDINE
Strength(s): 150 MG
Imprint: N 544 150
Manufacturer: NOVOPHARM.

Name: RANITIDINE
Strength(s): 150 MG
Imprint: par 544
Manufacturer: PAR PHARM.

Name: RANITIDINE
Strength(s): 300 MG
Imprint: GG 615
Manufacturer: GENEVA PHARM.

Name: RANITIDINE
Strength(s): 300 MG
Imprint: CD 130
Manufacturer: PAR PHARM.

Name: RANITIDINE
Strength(s): 300 MG
Imprint: par 545
Manufacturer: PAR PHARM.

Name: RANITIDINE
Strength(s): 300 MG
Imprint: N 547 300
Manufacturer: TEVA USA

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